Chemical name: 1,1'-Biphenyl, 2,2',3,3',4,4',5,5',6,6'-decabromo- Final regulatory action has been taken for the category: Industrial Final regulatory action: The chemical is Banned Use or uses prohibited by the final regulatory action: PBBs may not be used in textile articles intended to come in contact with the skin Use or uses that remain allowed: All other uses than the use in textile articles intended to come in contact with the skin are continued. The final regulatory action was based on a risk or hazard evaluation: No Summary of the final regulatory action: PBBs may not be used for the production of textile articles (clothes, underwear, bedclothes etc.) to come in contact with human skin. The reasons for the final regulatory action were relevant to: Human health Summary of known hazards and risks to human health: Short-term Toxicity: PBBs cause weight loss, liver damage, porphyria, effects on central nervous system, skin, eyes and immune system, effects on reproduction, they are weakly teratogenic (embryotoxic) in cattle and laboratory animals. NOEL (Fire-master BP) < 0.5 mg/kg bw (teratogenic effects, weight loss). Chronic Toxicity: IARC: inadequate evidence for carcinogenicity to humans, sufficient evidence for carcinogenicity in animals. ADI: no value estimated. Epidemiological data: A retrospective study was conducted in persons living in Michigan after accidental use of PBB in cattle feed. Symptoms were not correlated with PBB body burden. In lactating Michigan women PBB concentrations in milk were positively correlated with fat content. Food: No data available, other than following the accidental feed contamination in Michigan (1973) when levels in milk and meat products were collected. Occupational/Use: blood levels up to 85 /ug/l have been detected in employees. Date of entry into force of the final regulatory action: 01/01/2001 |